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Pregled bibliografske jedinice broj: 295323

Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin


Tomašić, Ana; Bertoša, Branimir; Tomić, Sanja; Šoškić, Milan; Magnus, Volker
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin // Journal of Chromatography. A, 1154 (2007), 1-2; 240-249 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 295323 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin

Autori
Tomašić, Ana ; Bertoša, Branimir ; Tomić, Sanja ; Šoškić, Milan ; Magnus, Volker

Izvornik
Journal of Chromatography. A (0021-9673) 1154 (2007), 1-2; 240-249

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
indole-3-acetic acid; IAA; amino acid conjugate; human serum albumin; ligand binding; lipophilicity; molecular conformation

Sažetak
The affinity of indole-3-acetic acid (IAA), indole-3-propionic acid, indole-3-butyric acid and 24 of their amino acid conjugates to immobilized human serum albumin, as expressed by the retention factor k (determined by HPLC), was dependent on (1) lipophilicity, (2) chirality and (3) functional groups in the amino acid moiety ; in some cases conformation plays an additional role. Two lipophilicity-related parameters afforded quantitative correlations with k: retention on a C-18 reversed-phase column (experimental approach) and the distance between the hydrophilic and hydrophobic poles of the molecules (in silico approach). Most compounds examined are possible metabolic precursors of IAA, an experimental tumor therapeutic.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija



POVEZANOST RADA


Projekti:
098-0982913-2829 - Molekularna regulacija biljnog razvitka (Salopek-Sondi, Branka, MZOS ) ( CroRIS)
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Tomić, Sanja, MZOS ) ( CroRIS)
178-0982929-2259 - Molekulsko prepoznavanje biljnih regulatora rasta (Šoškić, Milan, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Agronomski fakultet, Zagreb

Citiraj ovu publikaciju:

Tomašić, Ana; Bertoša, Branimir; Tomić, Sanja; Šoškić, Milan; Magnus, Volker
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin // Journal of Chromatography. A, 1154 (2007), 1-2; 240-249 (međunarodna recenzija, članak, znanstveni)
Tomašić, A., Bertoša, B., Tomić, S., Šoškić, M. & Magnus, V. (2007) Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin. Journal of Chromatography. A, 1154 (1-2), 240-249.
@article{article, author = {Toma\v{s}i\'{c}, Ana and Berto\v{s}a, Branimir and Tomi\'{c}, Sanja and \v{S}o\v{s}ki\'{c}, Milan and Magnus, Volker}, year = {2007}, pages = {240-249}, keywords = {indole-3-acetic acid, IAA, amino acid conjugate, human serum albumin, ligand binding, lipophilicity, molecular conformation}, journal = {Journal of Chromatography. A}, volume = {1154}, number = {1-2}, issn = {0021-9673}, title = {Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin}, keyword = {indole-3-acetic acid, IAA, amino acid conjugate, human serum albumin, ligand binding, lipophilicity, molecular conformation} }
@article{article, author = {Toma\v{s}i\'{c}, Ana and Berto\v{s}a, Branimir and Tomi\'{c}, Sanja and \v{S}o\v{s}ki\'{c}, Milan and Magnus, Volker}, year = {2007}, pages = {240-249}, keywords = {indole-3-acetic acid, IAA, amino acid conjugate, human serum albumin, ligand binding, lipophilicity, molecular conformation}, journal = {Journal of Chromatography. A}, volume = {1154}, number = {1-2}, issn = {0021-9673}, title = {Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin}, keyword = {indole-3-acetic acid, IAA, amino acid conjugate, human serum albumin, ligand binding, lipophilicity, molecular conformation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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