Pregled bibliografske jedinice broj: 295323
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin // Journal of Chromatography. A, 1154 (2007), 1-2; 240-249 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 295323 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin
Autori
Tomašić, Ana ; Bertoša, Branimir ; Tomić, Sanja ; Šoškić, Milan ; Magnus, Volker
Izvornik
Journal of Chromatography. A (0021-9673) 1154
(2007), 1-2;
240-249
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
indole-3-acetic acid; IAA; amino acid conjugate; human serum albumin; ligand binding; lipophilicity; molecular conformation
Sažetak
The affinity of indole-3-acetic acid (IAA), indole-3-propionic acid, indole-3-butyric acid and 24 of their amino acid conjugates to immobilized human serum albumin, as expressed by the retention factor k (determined by HPLC), was dependent on (1) lipophilicity, (2) chirality and (3) functional groups in the amino acid moiety ; in some cases conformation plays an additional role. Two lipophilicity-related parameters afforded quantitative correlations with k: retention on a C-18 reversed-phase column (experimental approach) and the distance between the hydrophilic and hydrophobic poles of the molecules (in silico approach). Most compounds examined are possible metabolic precursors of IAA, an experimental tumor therapeutic.
Izvorni jezik
Engleski
Znanstvena područja
Fizika, Kemija, Biologija
POVEZANOST RADA
Projekti:
098-0982913-2829 - Molekularna regulacija biljnog razvitka (Salopek-Sondi, Branka, MZOS ) ( CroRIS)
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Tomić, Sanja, MZOS ) ( CroRIS)
178-0982929-2259 - Molekulsko prepoznavanje biljnih regulatora rasta (Šoškić, Milan, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Agronomski fakultet, Zagreb
Profili:
Volker Magnus
(autor)
Ana Tomašić Paić
(autor)
Sanja Tomić
(autor)
Branimir Bertoša
(autor)
Milan Šoškić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Chemical Abstracts