Naslov
Ferritin and neuron-specific enolase in child neuroblastoma

Autori
Linarić, Irena ; Obuljen, Jasna ; Žižić, Vesna ; Nakić, Melita ; Stepan Giljević, Jasminka ; Ćurić, Dubravka ; Tadić, Igbala ; Leniček Krleža, Jasna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine. Spec.Suppl. / Gerard Siest, N. - Berlin : New York : Walter de Gruyter, 2003

Skup
15thIFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Barcelona, Španjolska, 01.06.2003. - 05.06.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ferritin; NSE; neuroblastoma; children

Sažetak
Neuroblastoma is the most common extracranial solid tumor in children and accounts for 7-10% of all tumors before the age of 15. Tumor markers ferritin and NSE (neuron specific enolase) correlate with clinical stage and have predictive value of neuroblastoma. Unfavorable prognostic factors are: ferritin concentration > 124 ng/ml, NSE concentration > 100 ng/ml, older age and amplified N-myc. In this study we showed results from 17 patients with neuroblastoma treated at the Children's Hospital Zagreb in period of 5 years. Patients were divided according to clinical stages II (n=5), III (N=7) and IV (N=5). Ferritin was measured in all patients at the time of diagnosis, before the 2. cycle of chemotherapy, at the end of chemotherapy and 3 months afther. NSE was measured in 16 patients at controlexamination 3 months afther the last cycle of chemotherapy. The aim of this study was to compare ferritin values at the the time of diagnosis, during and after chemotherapy, and compare ferriti and NSE values in different stages after chemotherapy. At the time of diagnosis significance different in ferritin concentration was found between stages II and III (p=0, 03, Mann-Whitney test). Chemotherapy showed no effect on ferritin values (p>0, 05, paired test). Spearmen correlation test showed no significance relationship (p>0, 05) between ferritin and NSE values. This are only preliminary results and futher studies involving higher numbers of patientare required for explaning the role of these tumor markers in neuroblastoma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA