Pregled bibliografske jedinice broj: 283368
INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS
INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS // Zbornik Radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006 / Sinanović, Osman ; Škorbić, Helena (ur.).
Mostar: Udruženje neurologa u Bosni i Hercegovini, 2006. str. 307-308 (poster, domaća recenzija, sažetak, znanstveni)
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Naslov
INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS
Autori
Filipović, Borid ; Bach-Rojecky, Lidija ; Lacković, Zdravko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Zbornik Radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006
/ Sinanović, Osman ; Škorbić, Helena - Mostar : Udruženje neurologa u Bosni i Hercegovini, 2006, 307-308
Skup
Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem
Mjesto i datum
Mostar, Bosna i Hercegovina, 09.11.2006. - 12.11.2006
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
botulinum toxin; orofacial pain; trigeminal ganglia
Sažetak
Aim. In the present study we investigated possible antinociceptive effect of botulinum toxin type A (BTX-A), injected into the trigeminal ganglion in orofacial pain in rats. Methods. Male Wistar rats were injected in right trigeminal ganglion with BTX-A 0.5 and 1 U/kg. Control rats were injected with saline. After 2-3 days, experimental orofacial pain was induced by one of the two inflammatory substances (1) formalin (2.5%) or (2) capsaicin (0.01%) which were injected into the right upper lip of rats. In both tests, the number of seconds that the animals spent rubbing/grooming the injected area was recorded. Statistical analysis was performed with Mann-Whitney U test. Results. BTX-A 1 U/kg, injected into the trigeminal ganglion 3 days before the induction of pain, significantly decreased the time that the rats spent rubbing the area injected with 0.01% capsaicin (rubbing time during 30 min for control: 219, 3 24, 2 s vs. 132, 4 17, 2 s for BTX-A-treatd animals, p<0.01). Intraganglionic injection of BTX-A in a dose 0.5 U/kg significantly reduced pain induced with formalin injection, too. The rubbing time was significantly decreased only in the second phase of the test (12-45 min following formalin injection). Rubbing time was 591, 9 26, 1 s for control group vs. 444, 3 31, 3 s for BTX-A-treated group (p<0.01). Conclusion. The present study demonstrates, for the first time, that low doses of BTX-A, applied in vivo into the trigeminal ganglion, reduce orofacial pain in rats.
Izvorni jezik
Engleski
POVEZANOST RADA
