Naslov
BOTULINUM TOXIN TYPE A IN NOCICEPTIVE, INFLAMATORY AND NEUROPATHIC PAIN

Autori
Lacković, Zdravko ; Bach-Rojecky Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006. / Osman Sinanović, Helena Škobić - Mostar : Udruženje neurologa u Bosni i Hercegovini, 2006, 63-64

Skup
Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006.

Mjesto i datum
Mostar, Bosna i Hercegovina, 09.11.2006. - 12.11.2006

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Domaća recenzija

Ključne riječi
botulinum toxin; SNAP-25; pain

Sažetak
Recent clinical observations suggest possible antinociceptive effect of botulinum toxin type A (BT-A) in different pain syndromes, for example in painful dystonias but also in migraine, various types of headache, postoperative pain etc. Based on clinical observations and limited number of preclinical investigations it was suggested that the antinociceptive effect might be a result of peripheral inhibition of neurotransmitter egzocytosis from nociceptive nerve endings - due to the cleavage of SNAP-25, one of the three key proteins in the process of egzocytosis. Contrary to that our results suggest that BT-A exerts antinociceptive effect which might include the upper parts of the nociceptive neuron where the toxin could interfere with processes of central sensitization. This new hypothesis is based on following observations: 1. We confirmed the effectiveness of BT-A in inflammatory, but not in nociceptive pain ; 2. for the first time, we demonstrated the effectiveness of BT-A in reducing experimental neuropathic pain and 3. The effects started on day 5 after peripheral application of BT-A in the rat hind paw-pad. 4. Investigating the suggested anti-inflammatory effect of BT-A, contrary to published experiments, we didn't find anti-inflammatory effect in two different models of experimental inflammation. 5. After intrathecal application, the lower doses of BT-A are effective and the effect starts within the first 24 h, 6. pharmacological inhibition of axonal transport with colchicine prevents the antinociceptive action of peripherally applied BT-A and 7. light chain of the toxin might be present in „ upper“ parts of nociceptive neurons according to immunohistochemistry and Western blots. Investigating the hypothesis about the possible interference of BT-A with central sensitization we showed that: 8. BT-A, after peripheral application, prevents secondary bilateral mechanical hyperalgesia induced by injection of acidic saline which is probably a consequence of central sensitization This observations suggests new mechanisms of antinociceptive action of BT-A. This is a challenge for future experiments in this field.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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