Naslov
Effect of botulinum toxin type A on hyperalgesia alloxan and streptozotocin induced diabetic neuropathy

Autori
Lacković, Zdravko ; Bach-Rojecky, Lidija ; Šalkovic-Petrišić, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract of the 15th World Congress of Pharmacology ; u: Acta Pharmacologica Sinica 27 (2006) (S1) / Vanhoute, Paul M. - Peking : Chinese Pharmacological Society, 2006, 312-312

Skup
World Congress of Pharmacology (15 ; 2006)

Mjesto i datum
Peking, Kina, 02.07.2006. - 07.07.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
botulinum toxin type A; neuropathic pain; antinociception; diabetes mellitus

Sažetak
Recently we found that botulinum toxin type A (BTX-A) reduced pain hypersensitivity in rats with surgical neuropathy (Bach-Rojecky at al. J. Neural Transm 2005 ; 112:215). Here we report that BTX-A has antinociceptive activity in diabetic neuropathy, too. Adult male Wistar rats were made diabetic by subcutaneous injection of alloxan or streptozotocin. After 5 days only animals with a tail-vein blood-glucose concentration of above 15 mmol/l were considered diabetic and included in the study. Paw-pressure and hot plate tests were first performed 3 weeks following betacitotoxic injection. Only the animals with significantly different mechanical thresholds compared to control group were considered neuropathic (hyperalgesic) and were than subjected to BTX-A treatment. On day 5 after BTX-A 5 and 7 U/kg treatment significant antinociceptive effect was observed i.e. diminished number of flinches and shakes of the formalin-injected paw. The lowest used dose (3 U/kg) was ineffective. With the paw pressure test results were practically the same. To our knowledge this is the first demonstration that a single peripheral injection of BTX might have antinociceptive effect in diabetic neuropathy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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