Naslov
Modulation of galectin-3 expression in monocyte-like cells by non-steroidal anti-inflammatory drugs

Autori
Dabelić, Sanja ; Dumić, Jerka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th Croatian Biological Congress-Proceedings of Abstracts / Besendorfer, Višnja ; Klobučar, Goran - Zagreb : Hrvatsko biološko društvo, 2006, OP-8

Skup
9th Croatian Biological Congress

Mjesto i datum
Rovinj, Hrvatska, 23.09.2006. - 29.09.2006

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
galectin-3; monocyte; anti-inflammatory drugs

Sažetak
During the last few decades, the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on numerous molecules and biological processes have been widely studied. Nevertheless, the relationship between anti-inflammatory drugs and lectin's expression/function is still to be elucidated. In this study we used human monocytic cell line THP-1 to investigate the effects of two most frequently used non-steroidal anti-inflammatory drugs (aspirin and indomethacin) on galectin-3, a multifunctional β -galactoside binding lectin which in general acts as a strong pro-inflammatory signal. The results showed that aspirin and indomethacin applied in clinically relevant doses affect both the gene (LGALS3) and protein expression level of galectin-3. The provoked changes on protein level are qualitatively and quantitatively different comparing to the effects on galectin-3 mRNA level, and depend on the activation state of the cell, drug type and applied concentration as well as time of the exposure. Our data revealed galectin-3 as a new target molecule of anti-inflammatory drugs, thus suggesting an additional pathway of their action on immune response.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA