Naslov
Does pertusis vaccination protect against allergy?

Autori
Radulović Pevec, Mira ; Pevec, Branko ; Stipić Marković, Asja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract book of XXV Congress of the European Academy of Allergology and Clinical Immunology / - Beč, 2006

Skup
XXV Congress of the European Academy of Allergology and Clinical Immunology

Mjesto i datum
Beč, Austrija, 10.06.2006. - 14.06.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pertussis; vaccination; allergic diseases; ISAAC

Sažetak
BACKGROUND The hygiene hypothesis postulates that frequent microbial exposure and infections early in life might prevent the development of allergic disease. Several studies suggested that vaccination is less protective against the onset of allergy than natural infection with viral or bacterial pathogens. Controlled prospective studies were provided to investigate pertussis vaccination and a risk of asthma/allergy development later in life, but they have not found any association. Only one study demonstrated a slightly increased allergic sensitivity in children with a history of pertussis infection. Data from supplementary modules of ISAAC questionnaires concerning pertussis vaccination and infection in a population of Croatian school-children will be presented. METHOD Original ISAAC questionnaires were distributed to all children (n = 1364) aged 10-11 years (4th grade) from 18 randomly selected elementary schools in a city of Zagreb. A total of 1047 questionnaires completed by subjects' parents were returned. Inconsistent responses were eliminated by phone-calling parents. Data were analyzed using SPSS software. The difference between investigated groups was calculated with Chi square test. A probability value of p<0.05 (two-tailed) indicated a statistically significant difference. RESULTS Subjects (n = 1047) were divided to allergic (n = 379) and non-allergic (n = 668) groups, according to whether they have or have not had symptoms of allergic diseases earlier in their lives. Pertussis vaccine has been received by 97.89% (n = 371) of subjects in allergic group, and 99.70% (n = 666) of subjects in non-allergic group, with statistically significant difference between groups (p=0.010). Pertussis infection has been acquired by 7.39% (n = 28) of subjects in allergic group, and 1.95% (n = 13) of subjects in non-allergic group, with statistically significant difference between groups (p<0.001). CONCLUSION Results of this investigation oppose the general claim that vaccination is less protective against allergies than natural infection. Pertussis vaccine might have a protective effect, and contrary, pertussis infection might enhance the onset of allergy. However, there is a possibility of bias, because only a small proportion of subjects have been exposed to natural pertussis infection. Confirmation of these results on a larger sample is needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA