Pregled bibliografske jedinice broj: 279140
Structure Elucidation of Bioorganic and Pharmaceutical Compounds by NMR Spectroscopy
Structure Elucidation of Bioorganic and Pharmaceutical Compounds by NMR Spectroscopy // Institute for Pharmaceutical Chemistry, University Graz / - (ur.).
Graz: -, 2003. str. - (pozvano predavanje, nije recenziran, neobjavljeni rad, znanstveni)
CROSBI ID: 279140 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Structure Elucidation of Bioorganic and Pharmaceutical Compounds by NMR Spectroscopy
Autori
Vikić-Topić, Dražen
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Izvornik
Institute for Pharmaceutical Chemistry, University Graz
/ - Graz, 2003
Skup
Institute for Pharmaceutical Chemistry, University Graz
Mjesto i datum
Graz, Austrija, 13.11.2003
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
NMR spectroscopy; structure elucidation
Sažetak
High-resolution NMR spectroscopy has become the main tool for structural elucidation of molecules in a liquide phase. NMR is used in organic chemistry and biochemistry, inorganic and physical chemistry, polymer chemistry, photochemistry etc. NMR enables determination the structure of bioorganic and biomolecules (proteins) up to 80 kD, in some cases even more than 100 kD. NMR studies of polymers including measuring of relaxation, spin diffusion and imaging give insight into their dynamics and morphology. Introduction of different substituents in molecule, like fluorine, bromine, etc., as well as isotopic labelling of molecules gives rise to substituent and isotopic effects on NMR spectral parameters (chemical shifts, spin-spin coupling constants and relaxation times), which can be useful in structure determination. In pharmaceutical chemistry C-F spin-spin coupling constants, especially long-range C-F couplings can be of great help since they show conformational dependence. Long-range deuterium istope effects on chemical shifts are also used in structural determination. In addition, mercuration of organic and bioorganic molecules show peculiar effects on chemical shifts, while Hg-C and Hg-H spin-spin coupling constants are also conformational dependent. CP MAS or MAR (cross polarization magic angle spinning / rotation) techniques, in solid state are opening new dimension in bioorganic and pharmaceutical chemistry (polymorphes), as well.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
