Naslov
Water soluble derivative of propolis and its polyphenolic compounds modulate immune response and increase tumoricidal activity of macrophages to Echrlich ascites tumor.

Autori
Oršolić, Nada ; Kosalec, Ivan ; Bašić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni

Izvornik
The Third German Bee products and Apitherapy Congress, Expo-2005, Course and Workshop / - Passau, 2005

Skup
The Third German Bee products and Apitherapy Congress, Expo-2005, Course and Workshop

Mjesto i datum
Passau, Njemačka, 01.04.2005. - 06.04.2005

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Propolis; Polyphenolic compounds; EAT tumor; Macrophages

Sažetak
Many plants and the plant-derived honeybee propolis have shown biological activities like immunomodulation and anti tumor effect. The effect of two water-soluble propolis derivatives (WSDP) from Croatia and Brazil, caffeic acid, quercetin, chrysin and naringenin which are present in WSDP was assessed on the development of Ehrlich ascites tumor (EAT). The compounds (50 mg kg-1) were given by gastric intubations (po) 2 hour prior to the intraperitoneal injection of EAT (2 x106) cells. It was observed that WSDP and its compounds effectively inhibited tumor growth and proliferation of EAT. The volume of ascitic fluid induced by EAT cells and total number of cells present in the peritoneal cavity was markedly reduced in EAT-bearing mice treated with test components. Treatment with test components increased the number of polymorphonuclear (PMN) cells and decreased the number of macrophages in the peritoneal cavity of treated animals. The macrophage spreading activity revealed that WSDP and all test compounds affected the functional state of macrophages increasing their tumoricidal activity. The effect of WSDP was most pronounced suggesting synergistic effect of components present in WSDP. It is likely that part of the anti tumor efficacy of the assayed components against EAT cells was the results of increased macrophage activity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA