Pregled bibliografske jedinice broj: 276411
In vivo efficacy of honey bee products in antimetastatic treatments of murine tumors alone or combened with chemotherapy.
In vivo efficacy of honey bee products in antimetastatic treatments of murine tumors alone or combened with chemotherapy. // Proceeding of the International Beekeeping Congress
Bangalore, 2005. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 276411 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
In vivo efficacy of honey bee products in antimetastatic treatments of murine tumors alone or combened with chemotherapy.
Autori
Oršolić, Nada ; Bašić, Ivan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Proceeding of the International Beekeeping Congress
/ - Bangalore, 2005
Skup
International Beekeeping Congress
Mjesto i datum
Bangalore, Indija, 13.11.2005. - 18.11.2005
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
chemoprevention; honey bee products; antimetastatic activity
Sažetak
We investigated the antimetastatic efficiency of water soluble derivative of propolis (WSDP) or honey given perorally (po) alone or in combination with chemotherapeutic agents. Transplantable murine tumors were used: a spontaneous mammary carcinoma (MCa) and a methylcholanthrene– induced fibrosarcoma (FS) of CBA mouse, and an anaplastic colon adenocarcinoma (ACa) of Y59 rat. Metastases in the lung were generated by injecting viable tumor cells intravenously (iv). WSDP exerted a significant antimetastatic effect (p < 0.05) when given either before or after tumor cell inoculation. In a combined treatment with WSDP and Epirubicin a profound inhibition of metastasis formation was found ; this synergistic effect is maximal when Epirubicin and WSDP were administrated after tumor cell inoculation. A pronounced antimetastatic effect (p < 0.05) was also achieved given alone or in combination of honey with 5-fluorouracil (5-FU) or Adiamycin (ADR) before tumor cell inoculation (2 g/kg for mice or 1 g/kg for rats, once a day for 7 consecutive days) as compared to control. However, honey given to animals after tumor cell inoculation enhanced metastastatic growth. Positive outcome of combined treatment with either propolis or honey and chemotherapeutics was expressed by the influence of these treatments on peripheral blood leukocytes. We have shown that a possible mechanism(s) of a combined treatment with chemotherapeutics and honey bee products could be the consequence of modulation of cytochrome P450 (CYP) enzymes included in biotransformation of chemotherapeutics. To conclude, these findings indicate that the combination of WSDP or honey with chemotherapeutics could increase the antimetastatic potential of chemotherapeutic agents and decrease their adverse effects such as leukopenia.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Hrvatski veterinarski institut, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb
