Naslov
Immunostimmulatory and antitumor activity of water-soluble derivative of propolis (WSDP)

Autori
Oršolić, Nada ; Macedo Fereire Alcici, Nivia ; Bendelja, Krešo ; Lojkić, Mirko ; Bašić, Ivan

Izvornik
Periodicum biologorum (0031-5362) 103 (2001); 255-261

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Immunomodulatin; propolis; macrophages; metastasis; mice

Sažetak
Background and purpose: It has been reported that a water-soluble derivative of propolis (WSDP) prevents experimental viral, bacterial and fungal infections via macrophage activation. The activated macrophages were shown to be a major component of host defense against neoplastic growth in experimental tumor sistems. The aim of this study was to investigate the potential antimetastatic activity of WSDP. Material and methods: WSDP was given ip at doses of 50 or 150 mg/kg before or after tumor cell inoculation. Its antimetastatic efficacy was examined on a transplantable spontaneous mammary carcinoma (MCA) of CBA mouse. Results: Both prophylactic and therapeutic applications of WSDP reduced the number of metastases in the lungs of mice. Changes in several immunological parameters such as production of LAF by peritoneal macrophages and the efficacy of those macrophages to kill tumor cell in vitro, responses of lymphocytes to mitogen, changes in weight and cellularity of spleen, and the ratio of CD4+ and CD8+ respectively, correlated well with antimetastatic properties of WSDP. WSDP exerted apoptotic activity in tumor but not in nontumorigenic cells. Conclusions: It is likely that antimetastatic activity of WSDP is mainly mediated by immunomodulatory activity and partially due to its apoptotic activity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA