Naslov
Propolis as a new potential immunomodulator in mice: antimetastatic activity of a water-soluble derivate of propolis (WSDP)

Autori
Oršolić, Nada ; Horvat Knežević, Anica ; Bašić, Ivan

Izvornik
Mellifera (1302-5821) 2 (2002); 29-46

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Immunomodulatin; propolis; macrophages; metastasis; mice

Sažetak
The antimetastatic efficacy of a water-soluble derivative of propolis (WSDP) was studid. Tumor was a transplantable mammary carcinoma (MCA) of CBA mouse. Metastasis in the lung were generated by 2x105 viable tumor cells intra venous (iv). WSDP was given intra peritoneal (ip) at doses of 50 or 150 mg/kg before or after tumor cell inoculation. Therapies reduced the number of metastases in the lung. It is likely that antimetastatic activity of the WSDP is mainly mediated by immunomodulatory activity. Changes in several immunological parameters such as production of activacting factor (LAF) by peritoneal macrophages and the efficacy of those macrophages to kill tumor cell in vitro, responses of lymphocytes to mitogen, and weight and cellularity of spleen, respectively, correlated well with antimetastatic properties of the WSDP. Based on results we postulate that the antimetastatic activity of propolis includes a pronounced immunomodulatory activity mainly toward augmentation of nonspecific antitumor resistence in mice via macrophage activation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA