Naslov
Radioprotective Effect of a Water - Soluble Derivative of Propolis in Mice

Autori
Oršolić, Nada ; Tadić, Zoran ; Benković, Vesna ; Horvat Knežević, Anica ; Lojkić, Mirko ; Bašić, Ivan

Izvornik
Mellifera (1302-5821) 4-8 (2004); 45-52

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Colony forming units (CFUs); Hematopoiesis; Mice; Propolis; Radioprotection

Sažetak
Radioprotection by a water - soluble derivative of propolis (WSDP) was investigated in the whole - body irradiated (WBI) CBA mice by  source. Protective effect was evaluated by colony forming efficacy, survival of mice and the levels of intracellular glutathione. Given perorally (po) 50 mg / kg to mice for 20 consecutive days WSDP prolonged the survival time of WBI mice with 5 - 9 Gy. The number of either endogenous or exogenous colony forming units in spleen (CFUs) was greater in WSDP - treated mice as compared to control. Using the exogenous CFUs assay, it was found that CFUs from the spleen of mice treated with WSDP were more resistant to irradiation than the CFUs from the spleen of normal mice ; the difference between surviving fraction of spleen CFUs from WSDP - treated and untreated mice was significant (< 0.05 and < 0.01). The radioprotective effect of propolis seems to be at least partially mediated by its effect on production of glutathione in hematopoietic tissue.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina

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