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Pregled bibliografske jedinice broj: 276124

The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines

Radić Stojković, Marijana; Piantanida, Ivo; Kralj, Marijeta; Marjanović, Marko; Žinić, Mladen; Pawlica, Dariusz; Eilmes, Julita
The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines // Bioorganic & medicinal chemistry, 15 (2007), 4; 1795-1801 doi:10.1016/j.bmc.2006.11.034 (međunarodna recenzija, članak, znanstveni)

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Naslov
The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines

Autori
Radić Stojković, Marijana ; Piantanida, Ivo ; Kralj, Marijeta ; Marjanović, Marko ; Žinić, Mladen ; Pawlica, Dariusz ; Eilmes, Julita

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 15 (2007), 4; 1795-1801

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antitumour agents ; dibenzotetraaza[14]annulenes ; DNA sequence selectivity ; intercalation ; groove binding

Sažetak
Three dibenzotetraaza[14]annulenes non-covalently interacted with double stranded DNA and RNA by mixed minor groove and/or intercalative binding mode. Observed interactions were strongly dependent on the steric exposure of positive charges and the length of the linkers of studied compounds as well as on the secondary structure and basepair composition of DNA/RNA. Compound 2 showed pronounced selectivity toward dA - dT rich sequences, and binding mode switch from dominant minor groove binding to ds-DNA to dominant intercalation into ds-RNA. Antiproliferative effect of studied compounds on human tumor and normal cell lines was in good agreement with the strength of observed interactions with DNA/RNA.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
098-0982904-2912 - Samo-udruživanje u gelovima i sinteza funkcionalnih hibridnih materijala (Frkanec, Leo, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marko Marjanović (autor)

Avatar Url Ivo Piantanida (autor)

Avatar Url Mladen Žinić (autor)

Avatar Url Marijana Radić Stojković (autor)

Avatar Url Marijeta Kralj (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Radić Stojković, Marijana; Piantanida, Ivo; Kralj, Marijeta; Marjanović, Marko; Žinić, Mladen; Pawlica, Dariusz; Eilmes, Julita
The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines // Bioorganic & medicinal chemistry, 15 (2007), 4; 1795-1801 doi:10.1016/j.bmc.2006.11.034 (međunarodna recenzija, članak, znanstveni)
Radić Stojković, M., Piantanida, I., Kralj, M., Marjanović, M., Žinić, M., Pawlica, D. & Eilmes, J. (2007) The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines. Bioorganic & medicinal chemistry, 15 (4), 1795-1801 doi:10.1016/j.bmc.2006.11.034.
@article{article, author = {Radi\'{c} Stojkovi\'{c}, Marijana and Piantanida, Ivo and Kralj, Marijeta and Marjanovi\'{c}, Marko and \v{Z}ini\'{c}, Mladen and Pawlica, Dariusz and Eilmes, Julita}, year = {2007}, pages = {1795-1801}, DOI = {10.1016/j.bmc.2006.11.034}, keywords = {antitumour agents, dibenzotetraaza[14]annulenes, DNA sequence selectivity, intercalation, groove binding}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2006.11.034}, volume = {15}, number = {4}, issn = {0968-0896}, title = {The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines}, keyword = {antitumour agents, dibenzotetraaza[14]annulenes, DNA sequence selectivity, intercalation, groove binding} }
@article{article, author = {Radi\'{c} Stojkovi\'{c}, Marijana and Piantanida, Ivo and Kralj, Marijeta and Marjanovi\'{c}, Marko and \v{Z}ini\'{c}, Mladen and Pawlica, Dariusz and Eilmes, Julita}, year = {2007}, pages = {1795-1801}, DOI = {10.1016/j.bmc.2006.11.034}, keywords = {antitumour agents, dibenzotetraaza[14]annulenes, DNA sequence selectivity, intercalation, groove binding}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2006.11.034}, volume = {15}, number = {4}, issn = {0968-0896}, title = {The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines}, keyword = {antitumour agents, dibenzotetraaza[14]annulenes, DNA sequence selectivity, intercalation, groove binding} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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