Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 271183

Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice


Girard Adam, Sonia; Caraux, Anouk; Fodil-Cornu, Nassima; Concepcion Loredo-Osti, J; Lesjean-Pottier, Sarah; Jaubert, Jean; Bubić, Ivan; Jonjić, Stipan; Guenet, Jean-Louis; Vidal, Silvia; Colucci, Francesco
Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice // Journal of Immunology, 176 (2006), 9; 5478-5485 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 271183 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice

Autori
Girard Adam, Sonia ; Caraux, Anouk ; Fodil-Cornu, Nassima ; Concepcion Loredo-Osti, J ; Lesjean-Pottier, Sarah ; Jaubert, Jean ; Bubić, Ivan ; Jonjić, Stipan ; Guenet, Jean-Louis ; Vidal, Silvia ; Colucci, Francesco

Izvornik
Journal of Immunology (0022-1767) 176 (2006), 9; 5478-5485

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cmv4; cytomegalovirus

Sažetak
CMV can cause life-threatening disease in immunodeficient hosts. Experimental infection in mice has revealed that the genetically determined natural resistance to murine CMV (MCMV) may be mediated either by direct recognition between the NK receptor Ly49H and the pathogen-encoded glycoprotein m157 or by epistatic interaction between Ly49P and the host MHC H-2Dk. Using stocks of wild-derived inbred mice as a source of genetic diversity, we found that PWK/Pas (PWK) mice were naturally resistant to MCMV. Depletion of NK cells subverted the resistance. Analysis of backcrosses to susceptible BALB/c mice revealed that the phenotype was controlled by a major dominant locus effect linked to the NK gene complex. Haplotype analysis of 41 polymorphic markers in the Ly49h region suggested that PWK mice may share a common ancestral origin with C57BL/6 mice ; in the latter, MCMV resistance is dependent on Ly49H-m157 interactions. Nevertheless, PWK mice retained viral resistance against m157- defective mutant MCMV. These results demonstrate the presence of yet another NK cell-dependent viral resistance mechanism, named Cmv4, which most likely encodes for a new NK activating receptor. Identification of Cmv4 will expand our understanding of the specificity of the innate recognition of infection by NK cells.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
0062004

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Stipan Jonjić (autor)

Avatar Url Ivan Bubić (autor)


Citiraj ovu publikaciju:

Girard Adam, Sonia; Caraux, Anouk; Fodil-Cornu, Nassima; Concepcion Loredo-Osti, J; Lesjean-Pottier, Sarah; Jaubert, Jean; Bubić, Ivan; Jonjić, Stipan; Guenet, Jean-Louis; Vidal, Silvia; Colucci, Francesco
Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice // Journal of Immunology, 176 (2006), 9; 5478-5485 (međunarodna recenzija, članak, znanstveni)
Girard Adam, S., Caraux, A., Fodil-Cornu, N., Concepcion Loredo-Osti, J., Lesjean-Pottier, S., Jaubert, J., Bubić, I., Jonjić, S., Guenet, J., Vidal, S. & Colucci, F. (2006) Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice. Journal of Immunology, 176 (9), 5478-5485.
@article{article, author = {Girard Adam, Sonia and Caraux, Anouk and Fodil-Cornu, Nassima and Concepcion Loredo-Osti, J and Lesjean-Pottier, Sarah and Jaubert, Jean and Bubi\'{c}, Ivan and Jonji\'{c}, Stipan and Guenet, Jean-Louis and Vidal, Silvia and Colucci, Francesco}, year = {2006}, pages = {5478-5485}, keywords = {Cmv4, cytomegalovirus}, journal = {Journal of Immunology}, volume = {176}, number = {9}, issn = {0022-1767}, title = {Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice}, keyword = {Cmv4, cytomegalovirus} }
@article{article, author = {Girard Adam, Sonia and Caraux, Anouk and Fodil-Cornu, Nassima and Concepcion Loredo-Osti, J and Lesjean-Pottier, Sarah and Jaubert, Jean and Bubi\'{c}, Ivan and Jonji\'{c}, Stipan and Guenet, Jean-Louis and Vidal, Silvia and Colucci, Francesco}, year = {2006}, pages = {5478-5485}, keywords = {Cmv4, cytomegalovirus}, journal = {Journal of Immunology}, volume = {176}, number = {9}, issn = {0022-1767}, title = {Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice}, keyword = {Cmv4, cytomegalovirus} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font