Naslov
Patient with Stiff person syndrome and negative anti-GAD antibodies

Autori
Brinar, Vesna ; Honnorat, Jerome ; Petelin, Željka ; Budišić, Zdenko ; Podolski, Paula

Izvornik
Neurologia Croatica (0353-8842) 55 (2006), 1/2; 27-33

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
stiff person syndrome; amphiphysin; glutamic acid decarboxylase; antibodies; breast carcinoma

Sažetak
Stiff person syndrome is a rare disorder of the central nervous system characterized by progressive rigidity and painful episodic spasms which are most prominently affecting paravertebral muscles and legs. According to past knowledge there are two variants of this syndrome. In most cases it is presented as autoimmune variant with positive antibodies against glutamic acid decarboxylase (GAD). Paraneoplastic variant is very rare and is connected with antiamphiphysin antibodies. Co-occurrence of both antibodies is unlikely. Authors describe a case of the patient with paraneoplastic Stiff person syndrome. At the beginning of the disease positive antiamphiphysin antibodies were revealed. Anti-GAD antibodies were negative. As a result of long-term and extensive diagnostic treatment the carcinoma of the left breast with metastases in axillary lymph nodes was revealed. Mastectomy with evacuation of axillary lymph nodes was performed, which was followed by chemotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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