Naslov
Specific Interactions between Sense and Complementary Peptides : What Can Molecular Dynamics Tell Us?

Autori
Smith, David M.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th International DU NMR Course and Conference / - Zagreb : Institut Ruđer Bošković, 2006

Skup
International DU NMR Course and Conference (5 ; 2006)

Mjesto i datum
Mali Ston, Hrvatska, 02.11.2006. - 05.11.2006

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
molecular dynamics; complementary peptides

Sažetak
Almost 40 years ago, it was suggested that sense and complementary (or anti-sense) peptides might be able interact on the basis of the specific recognition of complementary amino acid pairs. Since that time, the possible far-reaching ramifications of these interactions, including the provision of a basis for the proteomic code, have been investigated on a number of fronts. Despite the large body of evidence suggesting that the sense/anti-sense interactions play an important role in an extraordinarily diverse number of biological processes, the interactions themselves are still poorly understood at a fundamental level. In this contribution, we investigate an example pair of sense/anti-sense peptides using replica exchange molecular dynamics simulations. The results of these simulations provide a solid basis from which to investigate the aforementioned effects. In particular, it is shown that a computational approach has significant potential in terms of guiding further experimental studies.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA