Pregled bibliografske jedinice broj: 266638
The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself
The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself // Proceedings of the 6th International Cytokine Conference / Schwarzmeier, Josef D (ur.).
Bolonja: Medimond International Proceedings, 2007. str. 1-7 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 266638 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself
Autori
Aleksić, Joško ; Čulo, Melanie-Ivana ; Poljak, Ljiljana ; Matić, Tomas ; Čulo, Filip
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Proceedings of the 6th International Cytokine Conference
/ Schwarzmeier, Josef D - Bolonja : Medimond International Proceedings, 2007, 1-7
Skup
International Cytokine Conference (6 ; 2006)
Mjesto i datum
Beč, Austrija, 27.08.2006. - 31.08.2006
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
interleukin-1beta; IL-1alpha; IL-1Ra; acetaminophen; hepatoprotection
(interleukin-1beta; IL-1alpha IL-1Ra; acetaminophen; hepatoprotection)
Sažetak
The effect of mouse recombinant IL-1beta and its antagonists (IL-1Ra and rabbit polyclonal antibodies to mouse IL-1beta) on survival of animals and concentration of serum aminotransferases (AST and ALT) was investigated in mice intoxicated with acetaminophen (APAP). IL-1beta (1000 IU/mouse) or IL-1beta antibody (0.5 mL/mouse) were given i.p. 3 hours before APAP and IL-Ra (2.5 mg/mouse) half hour before APAP, which was administered by gastric lavage. IL-1beta significantly increased the survival mice and decreased plasma level of AST and ALT (p<0.05). Essentially, opposite effect had anti-IL-1beta antibodies and IL-1Ra. RT-PCR analysis has revealed that administration of APAP induces the expression of both IL-1beta and IL-1alpha in liver samples already 1 hour after its administration, indicating that the synthesis of these cytokines is part of host defense reaction to toxic effect of APAP. The expression of cytokines at induced by APAP administration could be blocked by pretreatment of mice with aspirin.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Napomena
Očekuje se da će se edicija, u kojoj je rad objavljen, biti indeksirana u CC.
POVEZANOST RADA
Projekti:
108-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre
Ustanove:
Medicinski fakultet, Zagreb
