Naslov
Jumping translocations involving 11q in a non-Hodgkin lymphoma

Autori
Petković, Iskra ; Konja, Josip ; Dominis, Mara ; Kaštelan, Maja

Izvornik
Cancer Genetics Cytogenetics (0165-4608) 114 (1999); 121-125

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Jumping translocation; non-Hodgkin lymphoma; child

Sažetak
This paper presents the results of a cytogenetic analysis in an 11-year-old boy with Non-hodgkin lymphoma. The investigation was performed on slides obtained from short-term culture of lympho node cells. The analyses revealed an abnormal clone with loss of the Y, gain of an X chromosome, t(3;22), trisomy 11 and three cytogenetically related subclones with jumping translocations involving 11q13 as the common breakpoint region. This region is an unusual site of chromosome breakage in jumping translocations, and has not been reported so far. Contrary to most published reports the jumping translocation in our patient is associated with long survival.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA