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Pregled bibliografske jedinice broj: 261331

Human decidual NK cell-mediated lysis of K562 transfectant cells

Juretic Frankovic, Koraljka; Laskarin, Gordana; Dupor, Jana; Strbo, Natasa; Bogovic Crncic, Tatjana; Bedenicki, Ivica; Srsen Medancic, Suzana; Veljkovic, Danijela; Randic, Ljiljana; Tabiasco, Julie et al.
Human decidual NK cell-mediated lysis of K562 transfectant cells // Second EMBIC Summer School "Molecular Mechanisms of Implantation" : Abstract book / Szekeres-Bartho, Julia (ur.).
Pečuh: Sveučilište u Pećuhu, 2006. str. 35-35 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 261331 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Human decidual NK cell-mediated lysis of K562 transfectant cells

Autori
Juretic Frankovic, Koraljka ; Laskarin, Gordana ; Dupor, Jana ; Strbo, Natasa ; Bogovic Crncic, Tatjana ; Bedenicki, Ivica ; Srsen Medancic, Suzana ; Veljkovic, Danijela ; Randic, Ljiljana ; Tabiasco, Julie ; Le Bouteiller, Philippe ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Second EMBIC Summer School "Molecular Mechanisms of Implantation" : Abstract book / Szekeres-Bartho, Julia - Pečuh : Sveučilište u Pećuhu, 2006, 35-35

Skup
EMBIC Summer School "Molecular Mechanisms of Implantation" (2 ; 2006(

Mjesto i datum
Pečuh, Mađarska, 01.07.2006. - 04.07.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NK cell; HLA-G; K562 transfectant cell

Sažetak
Problem: Interaction between NK cells and HLA-G-expressing cytotrophoblast cells plays a major role in regulating trophoblast invasion. We investigated the influence of HLA-G on FasL-mediated killing by decidual NK cells. Method of study: After density gradient isolation of decidual mononuclear cells, decidual lymphocytes were collected immediately or following 18 hour-culture in order to detect perforin and FasL mRNAs by RT-PCR. Cytotoxicity of magnetically separated CD56+ cells against K562 and K562-HLA-G was analyzed. Results: Overnight cultured decidual NK cells express FasL mRNA and are able to induce FasL protein expression in close contact with HLA-G molecule. Freshly isolated or overnight cultured CD56+ cells similarly lyse K562 and K562-HLA-G targets. FasL seems to represent a dominant mechanism of cytotoxicity for K562-HLA-G cells, while both perforin and FasL are equally involved in the lysis of K562. Conclusions: Since HLA-G induces FasL protein in NK cells, Fas/FasL-mediated killing could significantly contribute to K562-HLA-G lysis. Supported by the Ministry of Science and Technology, Republic of Croatia (Grant No. 0062029) and EMBIC (No. 512040, LSHM-CT-2004-512040).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
0062029

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Koraljka Juretić Franković (autor)

Avatar Url Tatjana Bogović Crnčić (autor)

Avatar Url Daniel Rukavina (autor)

Avatar Url Gordana Laškarin (autor)

Avatar Url Ljiljana Randić (autor)

Avatar Url Jana Ivković (autor)

Avatar Url Suzana Sršen Medančić (autor)

Avatar Url Danijela Veljković Vujaklija (autor)

Avatar Url Nataša Štrbo (autor)

Citiraj ovu publikaciju:

Juretic Frankovic, Koraljka; Laskarin, Gordana; Dupor, Jana; Strbo, Natasa; Bogovic Crncic, Tatjana; Bedenicki, Ivica; Srsen Medancic, Suzana; Veljkovic, Danijela; Randic, Ljiljana; Tabiasco, Julie et al.
Human decidual NK cell-mediated lysis of K562 transfectant cells // Second EMBIC Summer School "Molecular Mechanisms of Implantation" : Abstract book / Szekeres-Bartho, Julia (ur.).
Pečuh: Sveučilište u Pećuhu, 2006. str. 35-35 (poster, međunarodna recenzija, sažetak, znanstveni)
Juretic Frankovic, K., Laskarin, G., Dupor, J., Strbo, N., Bogovic Crncic, T., Bedenicki, I., Srsen Medancic, S., Veljkovic, D., Randic, L. & Tabiasco, J. (2006) Human decidual NK cell-mediated lysis of K562 transfectant cells. U: Szekeres-Bartho, J. (ur.)Second EMBIC Summer School "Molecular Mechanisms of Implantation" : Abstract book.
@article{article, author = {Juretic Frankovic, Koraljka and Laskarin, Gordana and Dupor, Jana and Strbo, Natasa and Bogovic Crncic, Tatjana and Bedenicki, Ivica and Srsen Medancic, Suzana and Veljkovic, Danijela and Randic, Ljiljana and Tabiasco, Julie and Le Bouteiller, Philippe and Rukavina, Daniel}, editor = {Szekeres-Bartho, J.}, year = {2006}, pages = {35-35}, keywords = {NK cell, HLA-G, K562 transfectant cell}, title = {Human decidual NK cell-mediated lysis of K562 transfectant cells}, keyword = {NK cell, HLA-G, K562 transfectant cell}, publisher = {Sveu\v{c}ili\v{s}te u Pe\'{c}uhu}, publisherplace = {Pe\v{c}uh, Ma\djarska} }
@article{article, author = {Juretic Frankovic, Koraljka and Laskarin, Gordana and Dupor, Jana and Strbo, Natasa and Bogovic Crncic, Tatjana and Bedenicki, Ivica and Srsen Medancic, Suzana and Veljkovic, Danijela and Randic, Ljiljana and Tabiasco, Julie and Le Bouteiller, Philippe and Rukavina, Daniel}, editor = {Szekeres-Bartho, J.}, year = {2006}, pages = {35-35}, keywords = {NK cell, HLA-G, K562 transfectant cell}, title = {Human decidual NK cell-mediated lysis of K562 transfectant cells}, keyword = {NK cell, HLA-G, K562 transfectant cell}, publisher = {Sveu\v{c}ili\v{s}te u Pe\'{c}uhu}, publisherplace = {Pe\v{c}uh, Ma\djarska} }

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