Naslov
Chromosomal aberrations and cancer risk: Results of a cohort study from Central Europe

Autori
Boffetta, P. ; van der Hel, O. ; Norppa, H. ; Fabianova, E. ; Fučić, Aleksandra ; Gundy, S. ; Lazutka, J. ; Cebulska-Wasilewska, A. ; Puskailerova, D. ; Znaor, A. ; Kelecsenyi, Z. ; Rachtan, J. ; Forni, A. ; Vermeulen, R. ; Bonassi, S.

Izvornik
American journal of epidemiology (0002-9262) 165 (2007), 1; 36-43

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chromosomal aberrations; cancer; cytogenetics; epidemiology

Sažetak
High level of chromosomal aberrations (CA) in peripheral blood lymphocytes may be an early marker of cancer risk, but data on risk of specific cancers and types of CA (chromosome-type [CSA] and chromatid-type [CTA] aberration) are limited. A total of 6430 healthy individuals from nine laboratories in Croatia, Hungary, Lithuania, Poland and Slovakia, included in CA surveys performed during 1978-2002, were followed-up for cancer incidence or mortality for an average of 8.5 years. 200 cancer cases were observed. Compared with the low tertile of CA level, the relative risk (RR) of cancer was 1.78 (95% confidence interval [CI] 1.19, 2.67) for medium tertile and 1.81 (95% CI 1.20, 2.73) for high tertile. The RR for CSA above vs. below the median was 1.50 (95% CI 1.12, 2.01), while that for CTA was 0.97 (95% CI 0.72, 1.31). The analyses of risk of specific cancers were limited by small numbers, but the association was stronger for stomach cancer. This study confirms the previously reported association between CA level and cancer risk and provides novel information on the type of aberrations more strongly predictive of cancer risk, on the types of cancer more strongly predicted by CA.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA