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Pregled bibliografske jedinice broj: 260165

Comparison of organic and inorganic mercury distribution in suckling rat


Orct, Tatjana; Blanuša, Maja; Lazarus, Maja; Varnai, Veda Marija; Kostial, Krista
Comparison of organic and inorganic mercury distribution in suckling rat // JAT. Journal of applied toxicology, 26 (2006), 6; 536-539 doi:10.1002/jat.1167 (međunarodna recenzija, kratko priopcenje, znanstveni)


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Naslov
Comparison of organic and inorganic mercury distribution in suckling rat

Autori
Orct, Tatjana ; Blanuša, Maja ; Lazarus, Maja ; Varnai, Veda Marija ; Kostial, Krista

Izvornik
JAT. Journal of applied toxicology (0260-437X) 26 (2006), 6; 536-539

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
blood; brain; ethylmercury; kidney; liver; mercury(2+) chloride; suckling rat; thiomersal; tissue distribution

Sažetak
Thiomersal is used as a preservative in vaccines given to small children.The metabolic product of thiomersal is ethylmercury and its distribution and kinetics are still not known, especially at this early age. The purpose of this study was to compare the body distribution of two forms of mercury: organic (thiomersal) and inorganic (mercury(2+) chloride) in very young, suckling rats. Mercury was applied subcutaneously three times during the suckling period on days 7, 9 and 11 of pups age, imitating vaccination of infants. A single dose of mercury was equimolar in both exposed groups i.e. 0.81 micromol Hg kg-1. At 14 days of age the animals were killed and total mercury analysed in blood and organs (kidney, liver and brain). The analytical method applied was total decomposition, amalgamation, atomic absorption spectrometry. The results showed that the level of mercury was higher in the liver and kidney of the inorganic mercury group than in the thiomersal exposed group. However, the brain and blood concentrations of mercury were higher in the thiomersal exposed group. These results need to be clarified by additional data on the kinetic pathways of ethylmercury compared with inorganic mercury.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
0022012

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Orct, Tatjana; Blanuša, Maja; Lazarus, Maja; Varnai, Veda Marija; Kostial, Krista
Comparison of organic and inorganic mercury distribution in suckling rat // JAT. Journal of applied toxicology, 26 (2006), 6; 536-539 doi:10.1002/jat.1167 (međunarodna recenzija, kratko priopcenje, znanstveni)
Orct, T., Blanuša, M., Lazarus, M., Varnai, V. & Kostial, K. (2006) Comparison of organic and inorganic mercury distribution in suckling rat. JAT. Journal of applied toxicology, 26 (6), 536-539 doi:10.1002/jat.1167.
@article{article, author = {Orct, Tatjana and Blanu\v{s}a, Maja and Lazarus, Maja and Varnai, Veda Marija and Kostial, Krista}, year = {2006}, pages = {536-539}, DOI = {10.1002/jat.1167}, keywords = {blood, brain, ethylmercury, kidney, liver, mercury(2+) chloride, suckling rat, thiomersal, tissue distribution}, journal = {JAT. Journal of applied toxicology}, doi = {10.1002/jat.1167}, volume = {26}, number = {6}, issn = {0260-437X}, title = {Comparison of organic and inorganic mercury distribution in suckling rat}, keyword = {blood, brain, ethylmercury, kidney, liver, mercury(2+) chloride, suckling rat, thiomersal, tissue distribution} }
@article{article, author = {Orct, Tatjana and Blanu\v{s}a, Maja and Lazarus, Maja and Varnai, Veda Marija and Kostial, Krista}, year = {2006}, pages = {536-539}, DOI = {10.1002/jat.1167}, keywords = {blood, brain, ethylmercury, kidney, liver, mercury(2+) chloride, suckling rat, thiomersal, tissue distribution}, journal = {JAT. Journal of applied toxicology}, doi = {10.1002/jat.1167}, volume = {26}, number = {6}, issn = {0260-437X}, title = {Comparison of organic and inorganic mercury distribution in suckling rat}, keyword = {blood, brain, ethylmercury, kidney, liver, mercury(2+) chloride, suckling rat, thiomersal, tissue distribution} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • BIOMED
  • PubMed
  • Research Alert


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