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Pregled bibliografske jedinice broj: 255738

Characteristics of the Craniofacial Complex in Turner Syndrome


Dumančić, Jelena; Kaić, Zvonimir; Lapter Varga, Marina; Lauc, Tomislav; Brkić, Hrvoje; Dumić, Miroslav
Characteristics of the Craniofacial Complex in Turner Syndrome // IADR PEF 2006, Abstracts
Dublin: International Association for Dental Research, 2006. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 255738 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Characteristics of the Craniofacial Complex in Turner Syndrome

Autori
Dumančić, Jelena ; Kaić, Zvonimir ; Lapter Varga, Marina ; Lauc, Tomislav ; Brkić, Hrvoje ; Dumić, Miroslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
IADR PEF 2006, Abstracts / - Dublin : International Association for Dental Research, 2006

Skup
International Association for Dental Research Pan European Federation 2006

Mjesto i datum
Dublin, Irska, 13.09.2006. - 16.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Turner syndrome; gonadal dysgenesis; cephalometry; X chromosome

Sažetak
Turner syndrome (TS) is an X chromosome abnormality of females that manifests with varying degrees of dysmorphic features. Objectives: The aim of the present research was to identify characteristics of the craniofacial complex in TS patients from Croatian population. Methods: Cephalometric analysis was carried out on lateral cephalograms of 36 TS patients, aged 10-33 years. There were 19 45, X patients and 17 with other X chromosome aberrations. Fourteen patients, aged 15-33, received estrogen-progestin hormone replacement therapy (HRT), while none received growth hormone therapy. Cephalograms of 72 eugnathic age-matched healthy females served as control. The analysis comprised 35 variables describing cranial base, maxilla, mandible, maxillomandibular and dental relations as described by Midtbo et al. (1996). Results: Logistic regression analysis showed that two variables were significant predictors of TS: posterior cranial base length (s-ba) and mandibular prognathism angle (s-n-sm). On average, s-ba distance was 3mm shorter and s-n-sm angle was 5° smaller than in controls. Sixty-four percent of TS patients and 92% of the controls were classified correctly. Factor analysis revealed clusters of TS patients and controls, formed due to differences in variables s-ba and s-n-sm. Factor rotation showed clusters forming due to differences in variables s-ba, nasion-sella-basion (n-s-ba) and subspinale-basion (ss-ba). On average, n-s-ba angle was 4° larger and ss-ba distance was 4mm shorter than in controls. None of the four variables correlated with age. There was no difference between the two TS kariotype subgroups or between TS patients taking HRT and those not taking HRT. Conclusion: The results indicated that deficient regulatory genes of the X chromosome in TS patients had a direct influence on all three anatomic parts - cranial base, maxilla and mandible – causing irregular growth. This study was supported by the Croatian Ministry of Science, Education and Sports, grants 3-02-383 and 0065004.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

Napomena
Dumančić Jelena s radom je osvojila International Association for Dental Research Continental European Division CED Travel Stipend 2006.



POVEZANOST RADA


Projekti:
0065004

Ustanove:
Stomatološki fakultet, Zagreb


Citiraj ovu publikaciju:

Dumančić, Jelena; Kaić, Zvonimir; Lapter Varga, Marina; Lauc, Tomislav; Brkić, Hrvoje; Dumić, Miroslav
Characteristics of the Craniofacial Complex in Turner Syndrome // IADR PEF 2006, Abstracts
Dublin: International Association for Dental Research, 2006. (poster, međunarodna recenzija, sažetak, znanstveni)
Dumančić, J., Kaić, Z., Lapter Varga, M., Lauc, T., Brkić, H. & Dumić, M. (2006) Characteristics of the Craniofacial Complex in Turner Syndrome. U: IADR PEF 2006, Abstracts.
@article{article, author = {Duman\v{c}i\'{c}, Jelena and Kai\'{c}, Zvonimir and Lapter Varga, Marina and Lauc, Tomislav and Brki\'{c}, Hrvoje and Dumi\'{c}, Miroslav}, year = {2006}, pages = {30}, keywords = {Turner syndrome, gonadal dysgenesis, cephalometry, X chromosome}, title = {Characteristics of the Craniofacial Complex in Turner Syndrome}, keyword = {Turner syndrome, gonadal dysgenesis, cephalometry, X chromosome}, publisher = {International Association for Dental Research}, publisherplace = {Dublin, Irska} }
@article{article, author = {Duman\v{c}i\'{c}, Jelena and Kai\'{c}, Zvonimir and Lapter Varga, Marina and Lauc, Tomislav and Brki\'{c}, Hrvoje and Dumi\'{c}, Miroslav}, year = {2006}, pages = {30}, keywords = {Turner syndrome, gonadal dysgenesis, cephalometry, X chromosome}, title = {Characteristics of the Craniofacial Complex in Turner Syndrome}, keyword = {Turner syndrome, gonadal dysgenesis, cephalometry, X chromosome}, publisher = {International Association for Dental Research}, publisherplace = {Dublin, Irska} }




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