Naslov
Cyclodextrin cellular delivery system for oligonucleotides

Autori
Agrawal, Sudhir ; Zhao, Qiuyan ; Habuš, Ivan

Broj patenta
US 5, 616, 565

Godina
1997

Datum patenta
01.04.1997.

Nositelj prava
Hybridon, Inc., Worcester, MA, US

Sažetak
Disclosed is a composition including an oligonucleotide complexed with a cyclodextrin. The oligonucleotide may be noncovalently associated with the cyclodextrin. Alternatively, the oligonucleotide may be covalently complexed with adamantane which is noncovalently associated with the cyclodextrin. Also disclosed are methods of enhancing the cellular uptake and intracellular concentration of oligonucleotides, methods of increasing the solubility of an oligonucleotide in a cell, and methods of treating a cell for viral infection or to prevent viral infection.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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