Pregled bibliografske jedinice broj: 255302
Base protecting groups and rapid process for oligonucleotide synthesis
Base protecting groups and rapid process for oligonucleotide synthesis
(2003)
CROSBI ID: 255302 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Base protecting groups and rapid process for oligonucleotide synthesis
Autori
Agrawal, Sudhir ; Iyer, Radhakrishnan, P. ; Habuš, Ivan ; Yu, Dong
Broj patenta
US 6, 509, 459
Godina
2003
Datum patenta
21.01.2003.
Nositelj prava
Hybridon, Inc., Cambridge, US
Sažetak
The invention provides new processes for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more rapid and/or more mild conditions than existing methods. The invention further provides a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups, as well as nucleoside synthons having such base protecting groups. The invention also provides oligonucleotides containing any of variety of base labile functionalities and methods for using such oligonucleotides.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
