Pregled bibliografske jedinice broj: 255192
Efficient and practical asymmetric synthesis of the taxol C-13 side chain and its analogs via chiral 3-hydroxy-4-aryl-beta-lactams
Efficient and practical asymmetric synthesis of the taxol C-13 side chain and its analogs via chiral 3-hydroxy-4-aryl-beta-lactams // Book of Abstract of 201st ACS National Meeting
Atlanta (GA), 1991. (poster, nije recenziran, sažetak, znanstveni)
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Naslov
Efficient and practical asymmetric synthesis of the taxol C-13 side chain and its analogs via chiral 3-hydroxy-4-aryl-beta-lactams
Autori
Ojima, Iwao ; Habuš, Ivan ; Zhao, M.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of Abstract of 201st ACS National Meeting
/ - Atlanta (GA), 1991
Skup
201st ACS National Meeting
Mjesto i datum
Atlanta (GA), Sjedinjene Američke Države, 14.04.1991. - 19.04.1991
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
chiral 3-hydroxy-4-aryl-beta-lactams; taxol
Sažetak
The lithium chiral ester enolate-imine cyclocondensation strategy is successfully applied to the asymmetric synthesis of the C-13 side chain of taxol, N-benzoyl-(2R, 3S)-3-phenylisoserine, and its analogs via 3-hydroxy-4-aryl-beta-lactams. This method provides the target molecules in 3 steps in good yield with virtually 100%e.e. The intermediate 3-hydroxy-beta-lactams can readily be coupled with a protected baccatin III after N-benzoylation and proper protection.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
