Pregled bibliografske jedinice broj: 255191
Asymmetric synthesis of beta-lactams by chiral ester enolate-imine condensation
Asymmetric synthesis of beta-lactams by chiral ester enolate-imine condensation // Abstract of Papers of 199th ACS National Meeting
Boston (MA), 1990. (poster, nije recenziran, sažetak, znanstveni)
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Naslov
Asymmetric synthesis of beta-lactams by chiral ester enolate-imine condensation
Autori
Ojima, Iwao ; Habuš, Ivan ; Silvestri, Kathryn, C.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstract of Papers of 199th ACS National Meeting
/ - Boston (MA), 1990
Skup
199th ACS National Meeting
Mjesto i datum
Boston (MA), Sjedinjene Američke Države, 22.04.1990. - 27.04.1990
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
beta-lactams; chiral ester enolate-imine condensation
Sažetak
Asymmetric cyclocondensation of N, N-bis(silyl)glycinates bearing chiral ester moieties with aldimines is found to proceed with extremely high enentioselectivity to give the corresponding chiral beta-lactams in good to high yields. It is found that the E/Z-geometry of the chiral ester-enolate is responsible for cis/trans stereochemistry of the beta-lactam formed. Effects of various chiral auxiliaries in the ester-enolates or the aldimines on the enentioselectivity of the reactions will be discussed.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
