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Pregled bibliografske jedinice broj: 25495

In Vitro Assessment of Asbestos Fibers Genotoxicity


Trošić, Ivančica; Brumen, Vlatka; Horvat, Đurđa
In Vitro Assessment of Asbestos Fibers Genotoxicity // Zentralblatt für Hygiene und Umweltmedizin, 199 (1997), 6; 558-567 (međunarodna recenzija, članak, znanstveni)


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Naslov
In Vitro Assessment of Asbestos Fibers Genotoxicity

Autori
Trošić, Ivančica ; Brumen, Vlatka ; Horvat, Đurđa

Izvornik
Zentralblatt für Hygiene und Umweltmedizin (0934-8859) 199 (1997), 6; 558-567

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
V 79 cell line; chrysotile asbestos; chromosomal aberration; sister chromatide exchange

Sažetak
This study was carried out in order to assess the genotoxic effect of in vitro exposure to commercial chrysotile asbestos. V 79 cell line, known as well-established cellular model, was used for detection of asbestos genotoxic potency. Conventional structural chromosomal aberration analysis and sister chromatide exchange (SCE) method were both used for asbestos genotoxicity assessment. Within the experimental protocol applied, V 79 cells were treated with asbestos in concentrations of 100 and 200um/ml F-10 (HAM) media during 90 days, respectively. Analysis of changes in chromosome structure as well as of cell ploidity was performed each tenth day of experimental course, consecutively. Two hundred well spread metaphases were taken into account for chromosomal aberration analysis. Frequency of sister chromatide exchange was observed in 50 cells per sample. The results of cytogenetic tests revealed structural chromosomal damages, SCE-elavation and changes in cell ploidity. Cytogenetic effect of asbestos obviously depended on dose applied and on the period of incubation. The results of this study suggest that significant cytogenetic changes occurring after asbestos treatment might directly or indirectly be a part of the biological events responsible for eliciting asbestos-induced carcinogenesis.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
00220205

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Vlatka Brumen (autor)

Avatar Url Ivančica Trošić (autor)

Avatar Url Đurđa Horvat (autor)


Citiraj ovu publikaciju:

Trošić, Ivančica; Brumen, Vlatka; Horvat, Đurđa
In Vitro Assessment of Asbestos Fibers Genotoxicity // Zentralblatt für Hygiene und Umweltmedizin, 199 (1997), 6; 558-567 (međunarodna recenzija, članak, znanstveni)
Trošić, I., Brumen, V. & Horvat, Đ. (1997) In Vitro Assessment of Asbestos Fibers Genotoxicity. Zentralblatt für Hygiene und Umweltmedizin, 199 (6), 558-567.
@article{article, author = {Tro\v{s}i\'{c}, Ivan\v{c}ica and Brumen, Vlatka and Horvat, \DJur\dja}, year = {1997}, pages = {558-567}, keywords = {V 79 cell line, chrysotile asbestos, chromosomal aberration, sister chromatide exchange}, journal = {Zentralblatt f\"{u}r Hygiene und Umweltmedizin}, volume = {199}, number = {6}, issn = {0934-8859}, title = {In Vitro Assessment of Asbestos Fibers Genotoxicity}, keyword = {V 79 cell line, chrysotile asbestos, chromosomal aberration, sister chromatide exchange} }
@article{article, author = {Tro\v{s}i\'{c}, Ivan\v{c}ica and Brumen, Vlatka and Horvat, \DJur\dja}, year = {1997}, pages = {558-567}, keywords = {V 79 cell line, chrysotile asbestos, chromosomal aberration, sister chromatide exchange}, journal = {Zentralblatt f\"{u}r Hygiene und Umweltmedizin}, volume = {199}, number = {6}, issn = {0934-8859}, title = {In Vitro Assessment of Asbestos Fibers Genotoxicity}, keyword = {V 79 cell line, chrysotile asbestos, chromosomal aberration, sister chromatide exchange} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • Index Medicus
  • Excerpta Medica
  • Environmental Mutagen Information Center





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