Pregled bibliografske jedinice broj: 254749
Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
(1999)
CROSBI ID: 254749 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
Autori
Iyer, Radhakrishnan P. ; Devlin, Theresa ; Habuš, Ivan ; Yu, Dong ; Agrawal, Sudhir
Broj patenta
US 5, 962, 674
Godina
1999
Datum patenta
5.10.1999.
Nositelj prava
Hybridon, Inc., Worchester, Mass, US
Sažetak
The invention provides new reagents and an improved process for synthesizing oligonucleotides that contain methylphosphonate internucleoside linkages. The reagents and process utilize a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
