Pregled bibliografske jedinice broj: 254709
Asymmetric synthesis of β-lactams by chiral ester enolate - imine condensation
Asymmetric synthesis of β-lactams by chiral ester enolate - imine condensation // Tetrahedron letters, 31 (1990), 30; 4289-4292 doi:10.1016/S0040-4039(00)97603-2 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 254709 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Asymmetric synthesis of β-lactams by chiral ester enolate - imine condensation
Autori
Ojima, Iwao ; Habuš, Ivan
Izvornik
Tetrahedron letters (0040-4039) 31
(1990), 30;
4289-4292
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
N, N-bis(silyl)glycinates ; chiral β-lactams ; ester-enolates
Sažetak
Asymmetric cyclocondensation of N, N-bis(silyl)glycinates bearing chiral ester moieties with aldimines is found to proceed with extremely high enantioselectivity to give the corresponding chiral β -lactams in good to high yields. It is found that the E/Z-geometry of the chiral ester-enolate is responsible for cis/trans stereochemistry of the β -lactam formed. Effects of various chiral auxiliaries in the ester-enolates on the enantioselectivity of the reactions are examined.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
