Naslov
The effect of chemical structure and stereochemistry on interactions of immunomodulatory peptides with lipid bilayers in liposomes

Autori
Frkanec, Ruža ; Travaš, Dijana ; Noethig-Laslo, Vesna ; Mirosavljević, Krunoslav ; Krstanović, Marina ; Vranešić, Branka ; Tomašić, Jelka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Peptide Science, Abstracts of the 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5.-10. 09. 2004. / - , 2004

Skup
3rd International and 28th European Peptide Symposium

Mjesto i datum
Prag, Češka Republika, 05.09.2004. - 10.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Peptidoglycan monomer; adamantyltripeptides; liposomes; ESR

Sažetak
The peptidoglycan monomer, GlcNAc-MurNAc-L-Ala-D-isoGlnmesoDAP-D-Ala-D-Ala (PGM), the natural compound originating from the Brevibacterium divaricatum peptidoglycan and its semisynthetic derivatives (Boc-Tyr-PGM and (Adamant-1-yl)-acetyl-PGM) and synthetic adamantyltripeptides D- and L-(adamant-2-yl)-Gly-L-Ala-D-isoGln were incorporated into liposomes. The interactions of incorporated compounds with phospholipids in liposomal bilayers were investigated by electron paramagnetic resonance spectroscopy. The spin labelled fatty acids, n-doxyl-stearic acids (n=5, 7, 16)were used to investigate the interaction of tested compounds with negatively charged multilamellar liposomes. The entrapment of the Boc-Tyr-PGM and adamantyltripeptides affected the motional properties of all spin labelled lipids, while the entrapment of PGM and (Adamant-1-yl)-acetyl-PGM had no effect.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA