Naslov
The metabolic fate of 14C-labeled peptidoglycan monomer in mice. Identification of the monomer and the corresponding pentapeptide in urine

Autori
Tomašić, Jelka ; Ladešić, Branko ; Valinger, Zdenka ; Hršak, Ivo

Izvornik
Biochimica Biophysica Acta (0304-4165) 629 (1980), 1; 77-82

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
peptidoglycan monomer ; peptidoglycan metabolism ; pentapeptide ; radioactive peptidoglycan monomer

Sažetak
The distribution of radioactive products in mouse urine following i.v. administration of the 14-C-labeled peptidoglycan monomer, GlcNAc-MurNAc-L-Ala-D-isoGln-meso-DAP-D-Ala-D-Ala, was studied. 60-80% of radioactivity was recovered within first 3 h, 4-8% in the next 3h and 2-7% in the following 18 h. The majority of the label was associated with the unchanged peptidoglycan monomer (42-56% of the dose). 14-21% of the label was incorporated into a compound which was isolated and tentatively identified as L-Ala-D-isoGln-mesoDAP-D-Ala-D-Ala. The kinetics of excretion and the distribution of radioactivity did not differ in immunized, when compared to non-immunized, mice.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA