Naslov
Laterality phenotypes in schizophrenia patients, their siblings and control subjects: associations with clinical and cognitive variables

Autori
Dragović, Milan ; Hammond, Geoff ; Badcock, C. Johanna ; Jablensky, Assen

Izvornik
British Journal of Psychiatry (0007-1250) 187 (2005); 221-228

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
laterality; schizophrenia; phenotype; cognition; handedness

Sažetak
Background: Various behavioural indices of brain lateralisation significantly intercorrelate, but current research in this area still focuses on single behavioural asymmetries, such as handedness. Aim: To describe a novel approach, which simultaneously integrates various laterality indices and delineates complex phenotypes. Method Grade of membership (GoM) analysis was used to describe latent, complex lateralisation phenotypes in schizophrenia patients, their siblings and controls. The indices used were: (i) asymmetries of eye, foot and hand ; (ii) hand motor proficiency ; and (iii) handedness of patient’ s first-degree relatives. Results: Three distinct pure types of lateralisation (‘ right’ , ‘ left’ and ‘ mixed’ ) were evident in patients compared to two (‘ right’ and ‘ left’ ) in siblings and controls. The ‘ mixed’ type in patients featured absence of eye and foot lateralisation, and presence of familial sinistrality, despite a right-hand dominance for writing. Patients with schizophrenia expressing the ‘ left’ phenotype had a more severe course of illness, significantly increased scores on two schizotypy factors and poorer neurocognitive performance. The pure types in the siblings were similar to those in healthy controls. Conclusions: The findings suggest that a leftward reversal, rather than a reduction in lateralisation, is associated with clinical severity and neurocognitive deficits in patients with schizophrenia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA