Naslov
Immunotherapy of B-16 melanoma with peptidoglycan monomer

Autori
Hršak, Ivo ; Tomašić, Jelka ; Osmak, Maja

Izvornik
European journal of cancer & clinical oncology (0277-5379) 19 (1983), 5; 681-686

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Peptidoglycan monomer ; B-16 melanoma ; antimetastatic activity ; phagocytic activity

Sažetak
B-16 melanoma bearing mice received i.v. or i.t. one or multiple injections of immunostimulatory peptidoglycan monomer (PGM). Multiple injections of PGM reduced the growth rate of tumor nodule on the leg, but did not significantly prolong the survival of tumor-bearing mice. 1 mg of PGM administered 3 or 7 days after tumor inoculation inhibited formation of spontaneous or induced pulmonary metastases. The inhibition reached approx. 50% of control values in saline treated mice. Addition of PGM to in vitro cultures of B-16 melanoma cells did not change their growth rate. The phagocytic activity in the lungs, but not in the spleen and liver, was significantly augmented 3 and 7 days after treatment with PGM. These data indicate that the antimetastatic potency of PGM is probably due to activation of local (pulmonary macrophages, and not due to direct cytotoxic effects on melanoma B-16 cells or to activation of systemic antineoplastic defence.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA