Naslov
Immunotherapy of Lewis lung carcinoma with hydrosoluble peptidoglycan monomer (PGM)

Autori
Sava, Gianni ; Giraldi, Tulio ; Tomašić, Jelka ; Hršak, Ivo

Izvornik
Cancer Immunology Immunotherapy (0340-7004) 15 (1983); 84-86

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Peptidoglycan monomer; Lewis lung carcinoma; antitumor activity; antimetastatic activity

Sažetak
Immunostimulatory peptidoglycan monomer was examined for its antitumor effects in C57BL mice bearing Lewis lung carcinoma. The formation of spontaneous lung metastases from s.c. tumor implants was significantly inhibited. The growth of s.c. primary tumors, including advanced ones, was also significantly inhibited, though to a less pronounced extent than the growth of metastases. The effects on metastases were evident with all treatment schedules used, whereas those on s.c. primary tumors were schedule dependent. The treatment with PGM was found to be therapeutically useful when combined with surgical removal of i.m. implants ; in conditions where a single post operative treatment was ineffective, combined post-operative and immediately pre-operative administration of PGM significantly increased (by 40%) the survival time of treated animals over that of controls undergoing surgery only.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA