Naslov
Podjedinice glikoproteinskih hormona u nefunkcionalnim adenomima hipofize.
(Glycoprotein subunits in nonfunctioning pituitary adenomas)

Autori
Breskovac, Ljiljana ; Plavšić, Vesna ; Koršić, Mirko ; Žarković, Neven ; Tomašić, Jelka ; Žarković, Kamelija ; Giljević, Zlatko ; Aganović, Izet ; Škorić, Tanja

Izvornik
Biochemia Medica (1330-0962) 8 (1998); 67-70

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
LH-beta; nefunkcionalni adenoma hipofize; TRH test
(Non functioning pituitary adenoma; LH subunits; LH-beta; TRH test)

Sažetak
The concentrations of luteinizing hormone alpha and beta subunits were measured in the sera of 33 patients with nonfunctioning pituitary adenomas (NFPA) and in 9 patients also in the cell culture media. LH-beta was measured by an in house method. Three out of 33 patients(9%) had elevated concentration of alpha subunit while LH-beta concentrations were not different than those in controls. In TRH test 18/33 patients (54.5%) had a significant increase in response of alpha-subunit and 13/33 a significant response of LH-beta. In vitro, 8/9 adenomas released alpha.subunit and 6/9 released LH-beta into the cell culture media. We got significant correlations between alpha-subunit release in vivo and in vitro and between alpha-subunit and LH-beta release in vitro and their responses in TRH test. In 7 patients with TRH test performed also after the surgery, the responses of LH-beta were significantly lower. By earlier identification of patients with NFPA the control of tumor growth might be improved. Subunit responses to TRH may also serve as a marker of treatment efficiency.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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