Pregled bibliografske jedinice broj: 251703
Antitumor and antimetastatic activity of the immunoadjuvant peptidoglycan monomer PGM in mice bearing MCa mammary carcinoma
Antitumor and antimetastatic activity of the immunoadjuvant peptidoglycan monomer PGM in mice bearing MCa mammary carcinoma // Cancer immunology and immunotherapy, 18 (1984), 1; 49-53 doi:10.1007/BF00205399 (međunarodna recenzija, članak, znanstveni)
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Naslov
Antitumor and antimetastatic activity of the immunoadjuvant peptidoglycan monomer PGM in mice bearing MCa mammary carcinoma
Autori
Sava, Gianni ; Tomašić, Jelka ; Hršak, Ivo
Izvornik
Cancer immunology and immunotherapy (0340-7004) 18
(1984), 1;
49-53
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
peptidoglycan monomer ; antitumor activity ; antimetastatic activity ; MCa mammary carcinoma
Sažetak
The antitumor and antimetastatic activities of the water-soluble immunostimulating peptidoglycan monomer (PGM) have been evaluated in CBA mice bearing MCa mammary carcinoma. The antineoplastic effects of PGM depend strictly on the dosage and treatment schedule used. Though a significant inhibition of primary tumor growth is observed over a wide range of dosages, only the i.v. administration of daily doses of 50mg/kg/day on days 1, 5, 10 and 15 inhibit spontaneous lung metastasis formation and in parallel prolongs the survival time of the treated mice. The combination of PGM treatment and surgery indicated that the timing of administration plays and important role in the overall effectiveness of this substance.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Imunološki zavod d.d.,
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
