Naslov
The Novel Sulfonamides of 15-Membered Azalides as Inhibitors of Resistant Streptococcus pyogenes Strain

Autori
Bukvić-Krajačić, Mirjana ; Novak, Predrag ; Cindrić, Mario ; Dumić, Miljenko ; Čikoš, Ana ; Brajša, Karmen ; Kujundžić, Nedjeljko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
J. Mex. Chem. Soc. / Guillermo Delago Lamas - Mérida : ISSN 1870-249X, 2006, 198-198

Skup
IUPAC ICOS-16. 16^th International Conference of Organic Synthesis

Mjesto i datum
Mérida, Meksiko, 11.06.2006. - 15.06.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
macrolide antibiotic ; macrolide-resistant Streptococcus pneumoniae ; Streptococcus pyogenes ; 9a-substituted azalide derivatives

Sažetak
Macrolide antibiotic azithromycin 1, the first representative of the azalide class, is well-established antimicrobial agent for a treatment of respiratory tract infections.[1] Due to the unexpectedly rapid emergence of macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes among clinical isolates, significant efforts have been devoted to the chemical modification of the existing macrolides. As part of our continuous synthetic efforts focused on a preparation of 9a-substituted azalide derivatives [2] we have recently reported the synthesis of novel sulfonylureas of 15-membered azalides which showed improved activity against inducible resistant S. pyogenes strains.[3] Those results prompted us to further explore modifications at position 9a of an azalide lacton ring, especially by the carbamoyl group linked sulfonamides, such as sulfanilamide, sulfabenz, sulfapyridine and sulfamethoxazole.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA