Naslov
Peptidoglycan Monomer Originating from Brevibacterium divaricatum - Its Metabolism and Biological Activities in the Host

Autori
Tomašić, Jelka ; Hršak, Ivo

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Surface Structures of Microorganisms and Their Interaction With the Mammalian Host. Workshop Proceedings / Schrinner, E. ; Richmond, M.H. ; Seibert G. ; Schwarz, U. - Weinheim : VCH Verlagsgesellschaft, 1988, 113-121

Skup
Surface Structures of Microorganisms and Their Interaction With the Mammalian Host. The Eighteenth Workshop Conference Hoechst

Mjesto i datum
Hamminkeln, Njemačka, 20.10.1987. - 23.10.1987

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
peptidoglycan monomer; metabolic fate of PGM; immunomodulating activity; antimalignant activity; drug metabolizing enzymes

Sažetak
Peptidoglycan monomer (PGM) is the disaccharide-pentapeptide originating from Brevibacterium divaricatum. It was obtained by lysozyme digestion of uncrosslinked peptidoglycan chains isolated from the culture fluid of penicillin treated bacteria. PGM preparation contains up to 10% of anhydromuramyl analogue. PGM is water soluble, non-pyrogenic and non-toxic. It is excreted rapidly in urine after i.v. administration, partly as a pentapeptide, resulting from the action of N-acetylmuramyl-L-alanine amidase present in blood. Biological activities of PGM exhibited in various experimental models include: stimulation of immune response, antitumor and antimetastatic activity, immunorestorative activity and inhibition of drug metabolizing enzymes in liver.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Biotehnologija

POVEZANOST RADA