Naslov
SMI-32 immunocytochemistry of the hippocampus and entorhinal cortex in schizophrenic patients

Autori
Šimić, Goran ; Radonić, Elizabeta ; Folnegović-Šmalc, Vera ; Petanjek, Zdravko ; Judaš, Miloš ; Kostović, Ivica

Izvornik
European journal of neuroscience (0953-816X) 8 (1995); 152-152

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
schizophrenia ; hippocampus ; entorhinal cortex ; nonphosphorylated neurofilaments

Sažetak
There is a growing evidence of structural alterations of the hippocampus and entorhinal cortex (EC) in a significant number of schizophrenic patients. We tried to access possible structural changes of pyramidal neurons using a method for demonstration of SMI-32 immunoreactivity (SMI-32 is an antibody against nonphosphorylated neurofilaments). Adult postmortal brains of two schizophrenic patients and three normal controls were analyzed. Compared to normal controls, the most prominent alterations in the brains of schizophrenic patients were found in CA1 field of hippocampus, particularly at the border with prosubiculum and CA2 field. In addition to the apparently reduced density of SMI- 32-immunoreactive (ir) neurons, some other abnormal features were observed. The most conspicious was the presence of parts of tortuous apical, as well as basal, dendrites of SMI-32-ir neurons. This alteration, similar to that found in fetal brains as a result of compression during development, was also found in CA2 field and occasionally in the deep layers of EC. Some neurons of the CA1 field which showed such changes had "wind- blown" dendrite deflections without a predominant direction. Our observations support the hypothesis of patchy neuronal disarray in the rostral part of the hippocampal pyramidal cell layer in the brain of schizophrenic patients. Moreover, a new, peculiar structural abnormality in a subpopulation of hippocampal projecting neurons, was found. This alteration, like neuronal disarray, could be a result of disordered embryogenesis. We concluded that further detailed quantitative analyses of the differences in number, distribution and morphology of SMI-32-ir neurons should better define a profile of schizophrenic temporal lobe structures and give more specific insights into the cellular pathology of this disorder.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA