Naslov
Design of peptide mimetics of HIV-1 gp120 for prevention and therapy of HIV disease

Autori
Veljković, N. ; Branch, Donald R. ; Metlaš, R. ; Prljić, J. ; Vlahoviček, Kristian ; Pongor, Sandor ; Veljković, Veljko

Izvornik
Journal of Peptide Research (1397-002X) 62 (2003), 4; 158-166

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HIV; peptide sintesys; gp120; peptide mimetics
(HIV; sinteza peptida; gp120; mimetika)

Sažetak
It has been reported that the C-terminus of the second conserved region (C2) of the envelope glycoprotein gp120, encompassing peptide RSANFTDNAKTIIVQLNESVEIN (NTM), is important for infectivity and neutralization of the human immunodeficiency virus type 1 (HIV-1). It was also demonstrated that human natural anti-vasoactive intestinal peptide (VIP) antibodies reactive with this gp120 region play an important role in control of HIV disease progression. The bioinformatic analysis based on the time-frequency signal processing revealed non-obvious similarities between NTM and VIP. When tested against a battery of sera from 46 AIDS patients, these peptides, in spite of a significant difference in their primary structures, showed a similar reactivity profiles (r = 0.83). Presented results point out that similarity in the periodical pattern of some physicochemical properties in primary structures of peptides plays a significant role in determination of their immunological crossreactivity. Based on these findings, we propose this bioinformatic criterion be used for design of VIP/NTM peptide mimetics for prevention and treatment of HIV disease.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Informacijske i komunikacijske znanosti

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