Naslov
Cancer in the families of children with leukaemia and lymphoma

Autori
Roganović, Jelena ; Radojčić Badovinac, Anđelka ; Buretić-Tomljanović, Alena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
5th Paediatric Alps-Adriaric Symposium : Abstracts ; u: Paediatria Croatica (ISSN 1330-1403 ) 4 (1997) (2) / - , 1997, 134-134

Skup
Paediatric Alps-Adriaric Symposium (5 ; 1997)

Mjesto i datum
Rijeka, Hrvatska, 04.06.1997. - 07.06.1997

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
leukaemia; lymphoma; genealogy; hereditary

Sažetak
Familial agregation has been reported for virtually every form of human cancer. Accordingly, many multiple-case families with haematological malignancies have been described and this has led to the suggestion of genetic susceptibility to these diseases. We conducted a family study of the occurrence of cancer in the relatives of 64 children affected by acute leukaemia and malignant lymphoma trearted at the Division of Haematology, Department of Paediatrics, University of Rijeka, Children's Hospital "Kantrida", in the perion from 1980 to1995. The information was otained from interviews with the parents of affected children regarding the occurrence and type of cancer in relatives. As often as possible, medical records and death certificates were sought for reported rumours and deaths. On the bases of the anamnestic data genealogical charts has been made. We found significant excess of cancer in the families of children affected by leukaemia and lymphoma. The higher frequency was obtainedfor the second generation relatives and maternal line. Independently of the age of the affected child, in most families, one or two additional family members had cancer. No typical tumor constellation was found, a specific hereditary pattern of cancer. The findings of this study suggest that genetic factors play an important role in the aetiology of haematological malignancies. Continued epidemiological and molecular genetic studies are needed to estimated precisely the inherited fraction of childhoodcancer and identify individuals at risk.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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