Naslov
Antiangiogenic effects of naphthalan in psoriasis

Autori
Vržogić, pero ; Lipozenčić, Jasna ; Jakić-Razumović, Jasminka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
3. Kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem / - , 2006

Skup
3. Kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem

Mjesto i datum
Split, Hrvatska, 18.05.2006. - 21.05.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Psoriasis; angigenesis; psoriasis

Sažetak
Psoriasis is Th1 cytokine disease and an angiogenesis-dependent disease and identifies vasoproliferation as a suitable target for the development of anti-psoriatic drug. However, advance in our understanding of the angioproliferation in psoriasis has been made only recently.The therapeutic implication the angiogenesis in psoriasis has been studied by many investigators. The factors that control angiogenesis in psoriasis are of interest. Therapeutic properties of Naphthalan, naphthene-based earth oil, is basis of antipsoriatic treatment regimen. Immunohistochemical analysis (cell immunophenotyp&not ; ing before and after 3 weeks of treatment with naphthalan oil) was performed on biopsy specimens from 10 patients with psoriasis vulgaris. To determine the angiogenetic fac&not ; tor in psoriatic lesions, immunohistochemical staining on 3-&micro ; m paraffin block sections was performed by using monoclonal anti-Factor VIII antibody. There was a significant difference in the mean number of new blood vessels before and after the therapy (15.1 vs. 6.7). It seems that naphthalan reduces number of new blood vessels and proved antiangiogenic properties in patients with psoriasis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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