Naslov
Diagnosis and treatment of asimptomatic HPV infection in men

Autori
Ljubojević, Suzana ; Lipozenčić, Jasna ; Skerlev, Mihael ; Žele-Starčević, Lidija ; Ljubojević, Nikola ; Babić, Damir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3. Kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem, : Program i knjiga sažetaka / - , 2006, 45-46

Skup
3. Kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem

Mjesto i datum
Split, Hrvatska, 18.05.2006. - 21.05.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
asimptomatic HPV infection in men

Sažetak
Genital human papilloma virus (HPV) is the most common viral sexually transmitted dis&not ; ; ease. HPV is associated with spectrum of diseases, from benign vulgar verruca, genital warts, to malignanat cervical, vulvar, anal or penile cancer. Genital warts are one of the most common HPV related benign lesions of the both male and female genitourinary tract. Male patients generally present no clinical lesions, and those that have female partner with cervical intraepihelial neoplasia (CIN) might constitute a reservoir for high&not ; ; risk HPV. Flat warts (condylomata plana) are subclilnical lesions that are difficult to detect without the special techniques (colposcopy-peniscopy) which involves 3-5% acetic acid, applied for 5-10 minutes. The HPV infected areas, whitened by the acetic acid, form so called “ accetowhitening” phenomenon. Subclinical lesions show histological evidence of HPV infection, either by presence of koilocytosis, or less frequently, intraepithelial neoplasia. Latent infections are defined by presence of HPV DNA in areas with no clinical or histo&not ; ; logical evidence of HPV infection. We suggest using peniscopy together with HPV DNA tests (Hybrid Capture II, PCR, in situ hybridization, Southern blots tests) and occasion&not ; ; ally, in suspected cases perform biopsy. Treatment for genital warts remains unsatisfactory, there is no cure for HPV infections and recurrences are common The following HPV infection treatments are available: pod&not ; ; ofilox, podophyllin, cryotherapy, topical 5-fluorouracil, trichloroacetic acid, intralesional interferon, systemic interferon, intralesional bleomycin, electrosurgery, classic and laser surgery. Imiquimod, a new topical immunotherapeutic agent, which induces interferon and other cytokines, has the potential to be a first-line therapy for genital warts. Men are usually reservoir of the virus, which lives in latent form on genital mucous mem&not ; ; branes, and this subclinical, asymptomatic infections can be oncogenic factor(s) in development of cervical cancer. Attention must be paid to control and early diagnosis to prevent neoplasic evolution.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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