Naslov
Synthesis of phenanthridinium bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumor activity of mono- and bis-nucleobase conjugates

Autori
Tumir, Lidija Marija ; Piantanida, Ivo ; Žinić, Mladen ; Juranović Cindrić, Iva ; Meić, Zlatko ; Kralj, Marijeta ; Tomić, Sanja

Izvornik
European Journal of Medicinal Chemistry (0223-5234) 41 (2006), 10; 1153-1166

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
phenanthridinium bis– nucleobase conjugates; nucleotides; polynucleotides; in vitro antitumor activity

Sažetak
Novel bis– nucleobase– phenanthridinium conjugates were synthesised and their aqueous solutions spectroscopically characterised. Bis– adenine conjugate revealed in aqueous solutions significantly more pronounced intramolecular aromatic stacking interactions than bis– uracil analogue. In contrast with previously reported poly A recognition by bis– uracil conjugate, recognition of complementary nucleotides and poly U was not observed due to the strong interference of bulk water with hydrogen bonding between nucleobases. The screening of anticancer activity on six human cell lines revealed that tethering of a nucleobase to phenanthridinium moiety diminished antiproliferative potential of phenanthridinium. However, among mono– nucleobase conjugates adenine derivative was found to be the most selective one (MiaPaCa– 2, Hep– 2).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA