Naslov
Platelet-activating factor acetylhydrolase activity and hsCRP level in sera of the patients on long-term hemodialysis

Autori
Tadijanović, M ; Flegar-Meštrić, Zlata ; Baričić, M ; Kosaka, T ; Juretić, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
16th IFCC-FESCC European congress of clinical biochemistry and laboratory medicine-EUROMEDLAB 2005, Glasgow, UK, May 8-12, 2005. Clinica Chimica Acta 2005 ; 355(suppl):S192 / - Glasgow, 2005

Skup
16th IFCC-FESCC European congress of clinical biochemistry and laboratory medicine-EUROMEDLAB 2005, Glasgow, UK, May 8-12, 2005.

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 08.05.2005. - 12.05.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
platelet-activiting factor acetylhydrolase (PAF-AH); LDL; HDL; uremic patients; long-term haemodialysis

Sažetak
The platelet-activiting factor acetylhydrolase (PAF-AH) circulates in human plasma complexed to lipoproteins, particularly LDL and HDL. It catalyzes hydrolysis of the sn-2-ester bond of platelet-activiting factor (PAF), which is mediator for allergic and inflammatory reactions. PAF-AH also degrades oxidized phospholipids on LDL that are closely associated with atherosclerosis. The aim of this study was to compare the serum PAF-AH activity and CRP level as a no specific marker of inflammation, in uremic patients under long-term haemodialysis. Patient group included 50 uremic patients who had been on regular haemodialysis with polysulfone membrane for an average of 7.7 years (range 1-20 years). PAF-AH activity (AZWELL Auto PAF-AH, Osaka, Japan) and sCRP level were measured on an Olympus AU600 automatic analyzer. Serum PAF-AH activity (411  103 U/L) of hemodialysed patients represented 129% (p 0.05) of control values while serum sCRP level varied between 0.135 to 4.32 mg/L. No difference in the PAF-AH activities ( 421  106 U/L ; 405  102 U/L) between the patients (19/50) with sCRP less than 2.0 mg/L and those with higher sCRP level (31/50) was detected. There was no correlation between PAF-AH activity and sCRP level (r=0.002). It might indicate that the changes in the PAF-AH activities are independent from the level of inflammation in the hemodialysed patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

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