Naslov
Effect of acarbose on alanine aminotransferase and aspartate aminotransferase activities in the liver of control and diabetic CBA mice

Autori
Petlevski, Roberta ; Hadžija, Mirko ; Lukač-Bajalo, Jana ; Juretić, Dubravka

Izvornik
Acta Pharmaceutica (1330-0075) 56 (2006), 1; 87-93

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acarbose; alanine aminotransferase; aspartate aminotransferase; diabetes

Sažetak
Acarbose, a complex oligosaharide that acts by competitive and reversible inhibition of small intestine brush-border alpha-glucosidases thereby delaying absorption of carbohydrates in the gut, is increasingly being used for the treatment of diabetes type II. The purpose of this study was to examine the short-term effects of diet containing 100 mg of acarbose mixed in 100 g standard laboratory chow, on specific liver enzyme activities: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in control and diabetic CBA mice. Diabetes was induced by intravenous injection of alloxan monohydrate in a dose of 75 mg kg-1 mouse body mass seven days before the treatment with acarbose. There were four groups of CBA mice in the experiment: control (C) mice (n=6) and diabetic (D) mice (n=8) fed with standard chow ; control (C/A-100) mice (n=8) and diabetic (D/A-100) mice (n=8) fed with mixture containing 100 mg acarbose per 100 g of standard chow. They were fed this diet ad libitum for seven days. Diabetes induced the decrease of the ALT catalytic activities to 69.6% of control value. Similar level of decreased ALT catalytic activity was detected in the liver of control and diabetic mice fed with chow containing 100 mg acarbose per 100 g. Changes in the specific and total activities of AST in the liver of the experimental groups were not observed. Better insight on the effect of acarbose on ALT and AST activity profiles could be seen using the higher amounts of acarbose and the monitoring of its metabolites in the liver.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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