Naslov
HLA Class II Gene and Haplotype diversity in the population of the Island of Hvar, Croatia

Autori
Grubić, Zorana ; Žunec, Renata ; Čečuk-Jelčić, Esma ; Kerhin-Brkljačić, Vesna ; Kaštelan, Darko ; Barać, Lovorka ; Janićijević, Branka ; Martinović, Irena ; Peričić, Marijana ; Bennett, Linda A. ; Rudan, Pavao ; Kaštelan, Andrija

Izvornik
Collegium Antropologicum (0350-6134) 22 (1998), 1; 157-168

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HLA Class II; the island of Hvar; population genetics; anthropology

Sažetak
The DRBl, DRB3, DRB5, DQA1 and DQB1 allele polymorphisms were analysed in 3 western and 3 eastern villages of the island of Hvar using PCR-SSOP method and l2th International Workshop primers and probes. Three DQB1 alleles (*0304, *0305, *0607) detected in the population of the island of Hvar (HP) have not yet been observed in general Croatian population (GCP). Significant differences were observed between two regions of Hvar for: a) DRB1 *0701 allele (p < 0. 001), b) DQA1 *0201 allele (p < 0.01), and c) DRB1 *0101 DQA1 *0101 DQB1 *0501 haplotyplc association (p < 0. 05). Two unusual haplotypic assoclations, which have not yet been described in general Croatian population (GCP), DRB1 *0101- DQA1 *0102 - DQB1 *0501 and DRB1 *1501- -DQA1 *0102 - DQB1*0604 were observed in the population from the island of Hvar (HP). Measures of genetic kinship and genetic distances revealed isolation and clusteri-sation which coincides with the known ethnohistorical, as well as biological and biocul-tural data obtalned from a series of previuos investigations. The five studied village subpopulations formed two clusters (East-West) to which the far eastern vlllage (with the highest rii of 0.0407) joined later, thus indicating possible impact of historical immi-grations from the mainland.

Izvorni jezik
Engleski

Znanstvena područja
Etnologija i antropologija

POVEZANOST RADA