Naslov
In vitro susceptibility of Klebsiella pneumoniae isolates to various antibiotics

Autori
Bedenić, Branka ; Fridrih, Sandra

Izvornik
Canadian Journal of Infectious Diseases (1180-2332) 6 (1995), Suppl C;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Klebsiella pneumoniae; microbial resistance; antibiotics
(Klebisella pneumoniae; microbial resistance; antibiotics)

Sažetak
The susceptibility to antibiotics of 53 clinical isolates of Klebsiella pneumoniae was tested by disc diffusion and broth microdilution method. The strains were highly resistant to penicillins (64.5% to amoxycillin, 60.3% to amoxycillin+clavulanic acid, 58% to piperacillin and 100% to ticarcillin) and to first and second generation of cephalosporins (57% to cefazoline, 54.7% to cephalexin, 47.1% to cefuroxime and 18.8% to cefoxitin). There was a high percentage of strains resistant to third generation cephalosporins too (52.8% to cefoperazone, 45.2% to ceftazidime, 22.6% to cefotaxime and 16.9% to ceftriaxone) and to aminoglycosides (50.9% to gentamicin and 41.5% to amikacin). MIC90 of amoxycillin, amoxycillin/clavulanic acid, cephalexin, cefuroxime, aztreonam, gentamicin, nalidixic acid and rifampicin was above 128 mg/L. MIc90 of ceftriaxone and cefpirome was 16 mg/L, of cefetamet 8 and of imipenem 0.5 mg/L. The stronges antimicrobial activity was observed with imipenem. All strains were resistant to rifampicin and susceptible to imipenem.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA