Naslov
Met-enkephalin effects on histamine-induced bronchoconstriction in guinea pigs

Autori
Tješić-Drinković, Dorian ; Štambuk, Nikola ; Tješić- Drinković, Duška ; Konjevoda, Paško ; Gotovac, Nikola ; Ćurković, Tihomir ; Votava-Raić, Ana

Izvornik
Collegium antropologicum (0350-6134) 29 (2005), 2; 689-692

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
met-enkephalin ; bronhoconstriction ; histamine ; asthma ; plethysmography

Sažetak
We investigated the effects of the neuropeptide met-enkephalin on histamine-induced bronhoconstriction in an experimental model of asthma. Classic Konzett and Roessler's method of whole body plethysmography modified by Gjurišl, was applied in the study. This method represents a standard experimental model of bronchoconstriction, suitable for the evaluation of peptide effects on the histamine-induced bronchoconstriction. The results of the measurements implicate a dose-related modulatory effect of met-enkephalin on the bronchoconstrictor action of histamine. Met-enkephalin doses of 1 mg/kg and 10 mg/kg, respectively, caused statistically significant reduction ofthe histamine-induced bronchoconstriction. Estimated ED50 dose was 0.235 mg/kg. Further studies are needed to define practical and therapeutical use of the presented observations in respiratory pharmacology.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA